Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area

Oksana Sulaieva; Natalia Obraztsova

doi:doi:10.11648/j.ajcem.20140203.11

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Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area

Oksana Sulaieva, Natalia Obraztsova

Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 3)

Received: 18 March 2014 Accepted: 28 April 2014 Published: 30 May 2014

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Abstract

Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.

Published in	American Journal of Clinical and Experimental Medicine (Volume 2, Issue 3)
DOI	10.11648/j.ajcem.20140203.11
Page(s)	42-46
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Gastroduodenal Pathology, Vagus Nerve, Acetylcholine, Immunomodulation

References

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APA Style

Oksana Sulaieva, Natalia Obraztsova. (2014). Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. American Journal of Clinical and Experimental Medicine, 2(3), 42-46. https://doi.org/10.11648/j.ajcem.20140203.11

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ACS Style

Oksana Sulaieva; Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am. J. Clin. Exp. Med. 2014, 2(3), 42-46. doi: 10.11648/j.ajcem.20140203.11

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AMA Style

Oksana Sulaieva, Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am J Clin Exp Med. 2014;2(3):42-46. doi: 10.11648/j.ajcem.20140203.11

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@article{10.11648/j.ajcem.20140203.11,
  author = {Oksana Sulaieva and Natalia Obraztsova},
  title = {Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {3},
  pages = {42-46},
  doi = {10.11648/j.ajcem.20140203.11},
  url = {https://doi.org/10.11648/j.ajcem.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140203.11},
  abstract = {Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.},
 year = {2014}
}

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TY  - JOUR
T1  - Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area
AU  - Oksana Sulaieva
AU  - Natalia Obraztsova
Y1  - 2014/05/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140203.11
DO  - 10.11648/j.ajcem.20140203.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 42
EP  - 46
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140203.11
AB  - Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.
VL  - 2
IS  - 3
ER  -

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Author Information

Oksana Sulaieva

Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine
Natalia Obraztsova

Department of Histology, Cytology and Embryology, M. Gorky Donetsk National Medical University, Ukraine

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Plain Text BibTeX RIS

APA Style

Oksana Sulaieva, Natalia Obraztsova. (2014). Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. American Journal of Clinical and Experimental Medicine, 2(3), 42-46. https://doi.org/10.11648/j.ajcem.20140203.11

Copy | Download

ACS Style

Oksana Sulaieva; Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am. J. Clin. Exp. Med. 2014, 2(3), 42-46. doi: 10.11648/j.ajcem.20140203.11

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AMA Style

Oksana Sulaieva, Natalia Obraztsova. Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area. Am J Clin Exp Med. 2014;2(3):42-46. doi: 10.11648/j.ajcem.20140203.11

Copy | Download

@article{10.11648/j.ajcem.20140203.11,
  author = {Oksana Sulaieva and Natalia Obraztsova},
  title = {Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {2},
  number = {3},
  pages = {42-46},
  doi = {10.11648/j.ajcem.20140203.11},
  url = {https://doi.org/10.11648/j.ajcem.20140203.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140203.11},
  abstract = {Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Immunomodulatory Effects of Vagus Nerve and Acetylcholine in Gastroduodenal Area
AU  - Oksana Sulaieva
AU  - Natalia Obraztsova
Y1  - 2014/05/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ajcem.20140203.11
DO  - 10.11648/j.ajcem.20140203.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 42
EP  - 46
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20140203.11
AB  - Objective: Neuroimmune interplay is one of the basic elements that determine mucosal health and disease. Continuing discussion of the vagus nerve in maintenance of homeostasis of gastroduodenal area, we aim to revise immunomodulating effects of acetylcholine. Results: Vagus nerve plays a major role in gut mucosa immunity due to cytoprotective properties and modulation of leukocytes activity. Stimulation of vagus nerve after mucosa damage is accompanied by cholinergic anti-inflammatory pathway that is realized directly through alfa7-nicotinergic cholinoreceptors on neutrophils, macrophages and lymphocytes, which activation causes decrease of NF-kB expression and TNF and IL-6 secretion. Indirect effect of acetylcholine through enteroendocrine cells regulation is quite important in determination of neuro-immune-endocrine interplay in gastroduodenal mucosa. In addition, the changes in vagus nerve activity and neurohumoral control of gastroduodenal area under antisecretory therapy of gastroduodenal diseases are deliberated in this review. Conclusion: Vagus nerve dysfunction is likely to be the main cause of gastroduodenal inflammation, dysregeneration and cancerogenesis.
VL  - 2
IS  - 3
ER  -

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