The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera

Mehmet Ali Uçar; Simten Dağdaş; Funda Ceran; Mesude Falay; Gülsüm Özet

doi:doi:10.11648/j.ajim.20190705.11

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The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera

Mehmet Ali Uçar, Simten Dağdaş, Funda Ceran, Mesude Falay, Gülsüm Özet

Published in American Journal of Internal Medicine (Volume 7, Issue 5)

Received: 3 July 2019 Accepted: 27 July 2019 Published: 14 August 2019

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Abstract

This study aimed to identify at what frequency of thromboembolic complications and the other risk factors that create a predisposition to thromboembolic complications occur in patients suffering from polycythemia vera (PV). In accordance with the 2001-2008 criteria put forth by World Health Organization, we reviewed the medical records of 207 patients who were diagnosed with PV between 2009 and 2017 at Ankara Numune Training and Research Hospital. We retrospectively looked at their demographical and clinical data, alongside their history of previous thrombotic events, what treatment they had received, and lab data at the time of diagnosis. We found that the mean hemoglobin and hematocrit levels, as well as their median white blood cell count and JAK2V617F positivity rate of those who had suffered thrombotic events were higher who had not. In addition, we also discovered that the mean age (60 vs. 55.3; p=0.012) and rate of tobacco use (62.9% vs. 23.7%; p<0.001) were both determined among the thrombotic groups versus the normal group. According to multivariate regression model of potential risk factors associated with thrombotic events, we had determined that smoking (OR=7.21; p<0.001), hypertension (OR=5.44; p=0.008), itching (OR=6.7; p=0.001), and JAK2V617F positivity (OR=2.61; p=0.043) were all independent risk factors that indicated the presence of an arterial event. We also arrived at the fact that smoking (OR=7.07; p=0.001) and itching (OR=12.9; p=0.001) were also independent risk factors predicting the presence of a venous event. Our findings conclusively reveal which risk factors are associated with thromboembolic events among PV patients. In light of that, we recommend that preventive measures be against these risk factors in order to decrease the frequency of thromboembolic complications that PV patients experience.

Published in	American Journal of Internal Medicine (Volume 7, Issue 5)
DOI	10.11648/j.ajim.20190705.11
Page(s)	112-117
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Polycythemia Vera, Thrombosis, JAK2 Mutation

References

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APA Style

Mehmet Ali Uçar, Simten Dağdaş, Funda Ceran, Mesude Falay, Gülsüm Özet. (2019). The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. American Journal of Internal Medicine, 7(5), 112-117. https://doi.org/10.11648/j.ajim.20190705.11

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ACS Style

Mehmet Ali Uçar; Simten Dağdaş; Funda Ceran; Mesude Falay; Gülsüm Özet. The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. Am. J. Intern. Med. 2019, 7(5), 112-117. doi: 10.11648/j.ajim.20190705.11

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AMA Style

Mehmet Ali Uçar, Simten Dağdaş, Funda Ceran, Mesude Falay, Gülsüm Özet. The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. Am J Intern Med. 2019;7(5):112-117. doi: 10.11648/j.ajim.20190705.11

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@article{10.11648/j.ajim.20190705.11,
  author = {Mehmet Ali Uçar and Simten Dağdaş and Funda Ceran and Mesude Falay and Gülsüm Özet},
  title = {The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera},
  journal = {American Journal of Internal Medicine},
  volume = {7},
  number = {5},
  pages = {112-117},
  doi = {10.11648/j.ajim.20190705.11},
  url = {https://doi.org/10.11648/j.ajim.20190705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190705.11},
  abstract = {This study aimed to identify at what frequency of thromboembolic complications and the other risk factors that create a predisposition to thromboembolic complications occur in patients suffering from polycythemia vera (PV). In accordance with the 2001-2008 criteria put forth by World Health Organization, we reviewed the medical records of 207 patients who were diagnosed with PV between 2009 and 2017 at Ankara Numune Training and Research Hospital. We retrospectively looked at their demographical and clinical data, alongside their history of previous thrombotic events, what treatment they had received, and lab data at the time of diagnosis. We found that the mean hemoglobin and hematocrit levels, as well as their median white blood cell count and JAK2V617F positivity rate of those who had suffered thrombotic events were higher who had not. In addition, we also discovered that the mean age (60 vs. 55.3; p=0.012) and rate of tobacco use (62.9% vs. 23.7%; p<0.001) were both determined among the thrombotic groups versus the normal group. According to multivariate regression model of potential risk factors associated with thrombotic events, we had determined that smoking (OR=7.21; p<0.001), hypertension (OR=5.44; p=0.008), itching (OR=6.7; p=0.001), and JAK2V617F positivity (OR=2.61; p=0.043) were all independent risk factors that indicated the presence of an arterial event. We also arrived at the fact that smoking (OR=7.07; p=0.001) and itching (OR=12.9; p=0.001) were also independent risk factors predicting the presence of a venous event. Our findings conclusively reveal which risk factors are associated with thromboembolic events among PV patients. In light of that, we recommend that preventive measures be against these risk factors in order to decrease the frequency of thromboembolic complications that PV patients experience.},
 year = {2019}
}

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TY  - JOUR
T1  - The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera
AU  - Mehmet Ali Uçar
AU  - Simten Dağdaş
AU  - Funda Ceran
AU  - Mesude Falay
AU  - Gülsüm Özet
Y1  - 2019/08/14
PY  - 2019
N1  - https://doi.org/10.11648/j.ajim.20190705.11
DO  - 10.11648/j.ajim.20190705.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 112
EP  - 117
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20190705.11
AB  - This study aimed to identify at what frequency of thromboembolic complications and the other risk factors that create a predisposition to thromboembolic complications occur in patients suffering from polycythemia vera (PV). In accordance with the 2001-2008 criteria put forth by World Health Organization, we reviewed the medical records of 207 patients who were diagnosed with PV between 2009 and 2017 at Ankara Numune Training and Research Hospital. We retrospectively looked at their demographical and clinical data, alongside their history of previous thrombotic events, what treatment they had received, and lab data at the time of diagnosis. We found that the mean hemoglobin and hematocrit levels, as well as their median white blood cell count and JAK2V617F positivity rate of those who had suffered thrombotic events were higher who had not. In addition, we also discovered that the mean age (60 vs. 55.3; p=0.012) and rate of tobacco use (62.9% vs. 23.7%; p<0.001) were both determined among the thrombotic groups versus the normal group. According to multivariate regression model of potential risk factors associated with thrombotic events, we had determined that smoking (OR=7.21; p<0.001), hypertension (OR=5.44; p=0.008), itching (OR=6.7; p=0.001), and JAK2V617F positivity (OR=2.61; p=0.043) were all independent risk factors that indicated the presence of an arterial event. We also arrived at the fact that smoking (OR=7.07; p=0.001) and itching (OR=12.9; p=0.001) were also independent risk factors predicting the presence of a venous event. Our findings conclusively reveal which risk factors are associated with thromboembolic events among PV patients. In light of that, we recommend that preventive measures be against these risk factors in order to decrease the frequency of thromboembolic complications that PV patients experience.
VL  - 7
IS  - 5
ER  -

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Author Information

Mehmet Ali Uçar
Simten Dağdaş
Funda Ceran

Department of Hematology, Ankara Numune Training and Research Hospital, Ankara, Turkey
Mesude Falay

Department of Hematology, Ankara Numune Training and Research Hospital, Ankara, Turkey
Gülsüm Özet

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APA Style

Mehmet Ali Uçar, Simten Dağdaş, Funda Ceran, Mesude Falay, Gülsüm Özet. (2019). The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. American Journal of Internal Medicine, 7(5), 112-117. https://doi.org/10.11648/j.ajim.20190705.11

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ACS Style

Mehmet Ali Uçar; Simten Dağdaş; Funda Ceran; Mesude Falay; Gülsüm Özet. The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. Am. J. Intern. Med. 2019, 7(5), 112-117. doi: 10.11648/j.ajim.20190705.11

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AMA Style

Mehmet Ali Uçar, Simten Dağdaş, Funda Ceran, Mesude Falay, Gülsüm Özet. The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera. Am J Intern Med. 2019;7(5):112-117. doi: 10.11648/j.ajim.20190705.11

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@article{10.11648/j.ajim.20190705.11,
  author = {Mehmet Ali Uçar and Simten Dağdaş and Funda Ceran and Mesude Falay and Gülsüm Özet},
  title = {The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera},
  journal = {American Journal of Internal Medicine},
  volume = {7},
  number = {5},
  pages = {112-117},
  doi = {10.11648/j.ajim.20190705.11},
  url = {https://doi.org/10.11648/j.ajim.20190705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20190705.11},
  abstract = {This study aimed to identify at what frequency of thromboembolic complications and the other risk factors that create a predisposition to thromboembolic complications occur in patients suffering from polycythemia vera (PV). In accordance with the 2001-2008 criteria put forth by World Health Organization, we reviewed the medical records of 207 patients who were diagnosed with PV between 2009 and 2017 at Ankara Numune Training and Research Hospital. We retrospectively looked at their demographical and clinical data, alongside their history of previous thrombotic events, what treatment they had received, and lab data at the time of diagnosis. We found that the mean hemoglobin and hematocrit levels, as well as their median white blood cell count and JAK2V617F positivity rate of those who had suffered thrombotic events were higher who had not. In addition, we also discovered that the mean age (60 vs. 55.3; p=0.012) and rate of tobacco use (62.9% vs. 23.7%; p<0.001) were both determined among the thrombotic groups versus the normal group. According to multivariate regression model of potential risk factors associated with thrombotic events, we had determined that smoking (OR=7.21; p<0.001), hypertension (OR=5.44; p=0.008), itching (OR=6.7; p=0.001), and JAK2V617F positivity (OR=2.61; p=0.043) were all independent risk factors that indicated the presence of an arterial event. We also arrived at the fact that smoking (OR=7.07; p=0.001) and itching (OR=12.9; p=0.001) were also independent risk factors predicting the presence of a venous event. Our findings conclusively reveal which risk factors are associated with thromboembolic events among PV patients. In light of that, we recommend that preventive measures be against these risk factors in order to decrease the frequency of thromboembolic complications that PV patients experience.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - The Frequency of Thromboembolism and Factors Associated with Thromboembolism in Patients Suffering from Polycythemia Vera
AU  - Mehmet Ali Uçar
AU  - Simten Dağdaş
AU  - Funda Ceran
AU  - Mesude Falay
AU  - Gülsüm Özet
Y1  - 2019/08/14
PY  - 2019
N1  - https://doi.org/10.11648/j.ajim.20190705.11
DO  - 10.11648/j.ajim.20190705.11
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 112
EP  - 117
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20190705.11
AB  - This study aimed to identify at what frequency of thromboembolic complications and the other risk factors that create a predisposition to thromboembolic complications occur in patients suffering from polycythemia vera (PV). In accordance with the 2001-2008 criteria put forth by World Health Organization, we reviewed the medical records of 207 patients who were diagnosed with PV between 2009 and 2017 at Ankara Numune Training and Research Hospital. We retrospectively looked at their demographical and clinical data, alongside their history of previous thrombotic events, what treatment they had received, and lab data at the time of diagnosis. We found that the mean hemoglobin and hematocrit levels, as well as their median white blood cell count and JAK2V617F positivity rate of those who had suffered thrombotic events were higher who had not. In addition, we also discovered that the mean age (60 vs. 55.3; p=0.012) and rate of tobacco use (62.9% vs. 23.7%; p<0.001) were both determined among the thrombotic groups versus the normal group. According to multivariate regression model of potential risk factors associated with thrombotic events, we had determined that smoking (OR=7.21; p<0.001), hypertension (OR=5.44; p=0.008), itching (OR=6.7; p=0.001), and JAK2V617F positivity (OR=2.61; p=0.043) were all independent risk factors that indicated the presence of an arterial event. We also arrived at the fact that smoking (OR=7.07; p=0.001) and itching (OR=12.9; p=0.001) were also independent risk factors predicting the presence of a venous event. Our findings conclusively reveal which risk factors are associated with thromboembolic events among PV patients. In light of that, we recommend that preventive measures be against these risk factors in order to decrease the frequency of thromboembolic complications that PV patients experience.
VL  - 7
IS  - 5
ER  -

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