Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.
| Published in | American Journal of Life Sciences (Volume 8, Issue 6) |
| DOI | 10.11648/j.ajls.20200806.11 |
| Page(s) | 183-188 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Probiotics, Inflammatory Bowel Diseases, Acetic Acid-induced Inflammation
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APA Style
Md Shihab Uddin Sohag, Mst. Mahfuza Rahman, Mollika Paul, Md. Masud Rana, Ranjan Kumar Barman, et al. (2020). Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. American Journal of Life Sciences, 8(6), 183-188. https://doi.org/10.11648/j.ajls.20200806.11
ACS Style
Md Shihab Uddin Sohag; Mst. Mahfuza Rahman; Mollika Paul; Md. Masud Rana; Ranjan Kumar Barman, et al. Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. Am. J. Life Sci. 2020, 8(6), 183-188. doi: 10.11648/j.ajls.20200806.11
AMA Style
Md Shihab Uddin Sohag, Mst. Mahfuza Rahman, Mollika Paul, Md. Masud Rana, Ranjan Kumar Barman, et al. Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon. Am J Life Sci. 2020;8(6):183-188. doi: 10.11648/j.ajls.20200806.11
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Download@article{10.11648/j.ajls.20200806.11,
author = {Md Shihab Uddin Sohag and Mst. Mahfuza Rahman and Mollika Paul and Md. Masud Rana and Ranjan Kumar Barman and Mir Imam Ibne Wahed and Md. Rafiqul Islam Khan},
title = {Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon},
journal = {American Journal of Life Sciences},
volume = {8},
number = {6},
pages = {183-188},
doi = {10.11648/j.ajls.20200806.11},
url = {https://doi.org/10.11648/j.ajls.20200806.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20200806.11},
abstract = {Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.},
year = {2020}
}
TY - JOUR T1 - Ameliorative Effect of Probiotic Strains, Lactobacillus Acidophilus and Lactobacillus Bulgaricus against Acetic Acid-Induced Inflammation in the Mouse Colon AU - Md Shihab Uddin Sohag AU - Mst. Mahfuza Rahman AU - Mollika Paul AU - Md. Masud Rana AU - Ranjan Kumar Barman AU - Mir Imam Ibne Wahed AU - Md. Rafiqul Islam Khan Y1 - 2020/11/23 PY - 2020 N1 - https://doi.org/10.11648/j.ajls.20200806.11 DO - 10.11648/j.ajls.20200806.11 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 183 EP - 188 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20200806.11 AB - Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both L. acidophilus and L. bulgaricus for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications. VL - 8 IS - 6 ER -
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