Copper oxide is a p-type semiconductor which has many applications in a different field. Copper oxide has excellent applications as an antioxidant, antibacterial, and antitumor or anticancer. Copper oxide nanoparticle combines with the cell membrane and enters into a cell; generate reactive oxygen specie (ROS), which causes oxidative stress in the cell. Oxidative stress leads to metastasis, cancer proliferation, apoptosis, DNA damage, cytotoxicity, and unregulated cell signaling. Hydroxyl free radical generated by Nanoparticles, combined with DNA and yield 8-hydroxyl-2-deoxyguanosine (8-OHdG), resultantly DNA is damaged. CuO nanoparticle shows antibacterial activity on different bacterial strains such as staphylococcus aureus, bacillus circulens BP2, Escherichia coli, and P. aeruginosa. Recently, CuO nanoparticles have applications in the detection of Cholesterol, lactate biosensor, DNA sequencing of microbe, and anti-HIV drug analysis. There is specialized CuO nanoparticle such as Glucose sensor, Hydrogen peroxide sensor, Immunosensor, Dopamine sensor for the detection of the different biomolecule. ROS generated by CuO nanoparticle causes toxicity, which leads to cell death. There is a fascinating area of research against tumors by nanoparticle use because of its antitumor nature. Metal nanoparticle exhibits anticancer activity due to physicochemical properties as antioxidant action or use of external stimuli. Free radical which are produced by the metal nanoparticle, kill cancer cells.
| Published in | International Journal of Computational and Theoretical Chemistry (Volume 8, Issue 2) |
| DOI | 10.11648/j.ijctc.20200802.12 |
| Page(s) | 40-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Copper Oxide Nanoparticle, Reactive Oxygen Specie (ROS), Sensors, Cancer Therapy, Biomedical Applications, Cytotoxicity and Toxicity
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APA Style
Sadaf Sarfraz, Akmal Javed, Shahzad Sharif Mughal, Muzammil Bashir, Abdul Rehman, et al. (2020). Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications. International Journal of Computational and Theoretical Chemistry, 8(2), 40-46. https://doi.org/10.11648/j.ijctc.20200802.12
ACS Style
Sadaf Sarfraz; Akmal Javed; Shahzad Sharif Mughal; Muzammil Bashir; Abdul Rehman, et al. Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications. Int. J. Comput. Theor. Chem. 2020, 8(2), 40-46. doi: 10.11648/j.ijctc.20200802.12
AMA Style
Sadaf Sarfraz, Akmal Javed, Shahzad Sharif Mughal, Muzammil Bashir, Abdul Rehman, et al. Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications. Int J Comput Theor Chem. 2020;8(2):40-46. doi: 10.11648/j.ijctc.20200802.12
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Download@article{10.11648/j.ijctc.20200802.12,
author = {Sadaf Sarfraz and Akmal Javed and Shahzad Sharif Mughal and Muzammil Bashir and Abdul Rehman and Sajida Parveen and Anam Khushi and Muhammad Kamran Khan},
title = {Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications},
journal = {International Journal of Computational and Theoretical Chemistry},
volume = {8},
number = {2},
pages = {40-46},
doi = {10.11648/j.ijctc.20200802.12},
url = {https://doi.org/10.11648/j.ijctc.20200802.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijctc.20200802.12},
abstract = {Copper oxide is a p-type semiconductor which has many applications in a different field. Copper oxide has excellent applications as an antioxidant, antibacterial, and antitumor or anticancer. Copper oxide nanoparticle combines with the cell membrane and enters into a cell; generate reactive oxygen specie (ROS), which causes oxidative stress in the cell. Oxidative stress leads to metastasis, cancer proliferation, apoptosis, DNA damage, cytotoxicity, and unregulated cell signaling. Hydroxyl free radical generated by Nanoparticles, combined with DNA and yield 8-hydroxyl-2-deoxyguanosine (8-OHdG), resultantly DNA is damaged. CuO nanoparticle shows antibacterial activity on different bacterial strains such as staphylococcus aureus, bacillus circulens BP2, Escherichia coli, and P. aeruginosa. Recently, CuO nanoparticles have applications in the detection of Cholesterol, lactate biosensor, DNA sequencing of microbe, and anti-HIV drug analysis. There is specialized CuO nanoparticle such as Glucose sensor, Hydrogen peroxide sensor, Immunosensor, Dopamine sensor for the detection of the different biomolecule. ROS generated by CuO nanoparticle causes toxicity, which leads to cell death. There is a fascinating area of research against tumors by nanoparticle use because of its antitumor nature. Metal nanoparticle exhibits anticancer activity due to physicochemical properties as antioxidant action or use of external stimuli. Free radical which are produced by the metal nanoparticle, kill cancer cells.},
year = {2020}
}
TY - JOUR T1 - Copper Oxide Nanoparticles: Reactive Oxygen Species Generation and Biomedical Applications AU - Sadaf Sarfraz AU - Akmal Javed AU - Shahzad Sharif Mughal AU - Muzammil Bashir AU - Abdul Rehman AU - Sajida Parveen AU - Anam Khushi AU - Muhammad Kamran Khan Y1 - 2020/11/19 PY - 2020 N1 - https://doi.org/10.11648/j.ijctc.20200802.12 DO - 10.11648/j.ijctc.20200802.12 T2 - International Journal of Computational and Theoretical Chemistry JF - International Journal of Computational and Theoretical Chemistry JO - International Journal of Computational and Theoretical Chemistry SP - 40 EP - 46 PB - Science Publishing Group SN - 2376-7308 UR - https://doi.org/10.11648/j.ijctc.20200802.12 AB - Copper oxide is a p-type semiconductor which has many applications in a different field. Copper oxide has excellent applications as an antioxidant, antibacterial, and antitumor or anticancer. Copper oxide nanoparticle combines with the cell membrane and enters into a cell; generate reactive oxygen specie (ROS), which causes oxidative stress in the cell. Oxidative stress leads to metastasis, cancer proliferation, apoptosis, DNA damage, cytotoxicity, and unregulated cell signaling. Hydroxyl free radical generated by Nanoparticles, combined with DNA and yield 8-hydroxyl-2-deoxyguanosine (8-OHdG), resultantly DNA is damaged. CuO nanoparticle shows antibacterial activity on different bacterial strains such as staphylococcus aureus, bacillus circulens BP2, Escherichia coli, and P. aeruginosa. Recently, CuO nanoparticles have applications in the detection of Cholesterol, lactate biosensor, DNA sequencing of microbe, and anti-HIV drug analysis. There is specialized CuO nanoparticle such as Glucose sensor, Hydrogen peroxide sensor, Immunosensor, Dopamine sensor for the detection of the different biomolecule. ROS generated by CuO nanoparticle causes toxicity, which leads to cell death. There is a fascinating area of research against tumors by nanoparticle use because of its antitumor nature. Metal nanoparticle exhibits anticancer activity due to physicochemical properties as antioxidant action or use of external stimuli. Free radical which are produced by the metal nanoparticle, kill cancer cells. VL - 8 IS - 2 ER -
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