In 1947 Dr. Nicolai Lazarev introduced the term “adaptogen” in order to define special plant-derived extracts like Ginseng, which seemed to help to cope with stress-induced physical and psychic weakness. Extracts from Rhodiola rosea L. were recognized to belong to this category of food supplements. Due to contradictory results in the literature it was decided to examine the neurophysiological effect of Rhodiola rosea extract on surrogate parameters of cognitive and emotional brain processing in 20 volunteers. Spectral signatures of regional electric brain activity were recorded under control of an Eye-Tracking device, by means of which different challenges were presented. Among the cognitive challenges was a Stroop test, a memory test and a picture comparison for search of small deviations; among the emotional challenges were three pictures:a crying child, a bird spider and a picture taken from the TV series “Jungle Camp”. Additionally, three film excerpts were shown: a boring and an exciting animal film as well as a horror trailer. Evaluation of all challenges against looking at a fixation cross on the screen revealed highly statistically significant differences. These consisted (among others) in considerable higher spectral power values of delta and theta power in frontal and occipital brain areas during all cognitive and emotional tasks except for the crying child and bird spider, where only occipital power increased. Exactly these parameters changed in the presence of Rhodiola rosea extract, where increases of delta and theta power in these regions were documented in comparison to placebo. These statistically significant increases indicate mental activation according to literature. Likewise, an increase of alpha2 spectral power was observed during performance of the memory test indicating activation of memory processes as known from literature. In summary, the extract from Rhodiola rosea modulated cognitive and emotional surrogate parameters indicating improvement of mental processing in a stimulatory and activating sense.
| Published in | International Journal of Nutrition and Food Sciences (Volume 3, Issue 3) |
| DOI | 10.11648/j.ijnfs.20140303.14 |
| Page(s) | 157-165 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Rhodiola rosea, EEG, Eye-Tracking, Neurocode-Tracking, Cognition, Emotion, CATEEM
| [1] | Dimpfel W, Pischel I, Lehnfeld R (2004) Effects of Lozenge Containing Lavender Oil, Extracts from Hops, Lemon Balm and Oat on Electrical Brain Activity of Volunteers. Eur J Med Res 9, 423-431. |
| [2] | Dimpfel W, Koch K, Weiss G (2011) Early effect of NEURAPAS® balance on current source density (CSD) of human EEG. BMC Psychiatry 11, 123-138. |
| [3] | Schober F, Schellenberg R, Dimpfel W (1995) Reflection of mental exercise in the dynamic quantitative topographical EEG. Neuropsychobiology, 31, 98-112. |
| [4] | Dimpfel W, Todorova A, Vonderheid-Guth B (1999) Pharmacodynamic properties of St. John's Wort. A single-blind neurophysiological study in healthy subjects comparing two commercial preparations. Eur J Med Res 4, 303-312. |
| [5] | Dimpfel W, Kler A, Kriesl E, Lehnfeld R und Keplinger-Dimpfel I.K (2006) Neurophysiological characterization of functionally active drink containing extracts of ginkgo and ginseng by source density analysis of the human EEG. Nu-tritional Neuroscience 9, 213-224. |
| [6] | Prichep LS, John ER, Ferris SH, Rausch L, Fang Z, Can-cro R, Torossian C Reisberg B (2006) Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging.Neurobiol Aging 27, 471-481. |
| [7] | Ishaque S, Shamseer L, Bukutu C, Vohra S (2012)Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med. 12:70. |
| [8] | Dimpfel W (2013) Pharmacological classification of herbal extracts by means of comparison to spectral EEG signatures induced by synthetic drugs in the freely moving rat.Journal of Ethnopharmacology; Vol 149: 2, 583-589. |
| [9] | Dimpfel W (2011) Simultaneous Eye-Tracking and Fast Dynamic EEG Current Source Density Imaging for Assessment of Commercials or Websites.6th European Confe-rence on Eye Movements ECM 2011, Marseille, France. |
| [10] | Dimpfel W, Hofmann HC (2014) Neurocode-Tracking based on Quantitative Fast Dynamic EEG Recording in Combination with Eye-Tracking. World J of Neuroscience 4, 106-119. DOI: 10.4236/wjns.2014.42013. |
| [11] | Dimpfel W (2011) Enkephaloglyphen: Spektrale Signaturen der elektrischen Gehirntätigkeit als Spiegel der Psyche. Verlag Books on Demand , Norderstedt, Germany. ISBN 978-3-8448-8208-7. |
| [12] | Jasper HH (1958) The ten-twenty electrode system of the Interna-tional Federation. ElectroencephalographyClinicalNeurophysiology 10, 371-5. |
| [13] | Gevins A, Smith ME, McEvoy L, Yu D (1997) High-resolution EEG mapping of cortical activation related to working memory: effects of task difficulty, typ of processing, and practice. Cerebral Cortex 7, 374-385. |
| [14] | Dimpfel W, Wedekind W, Keplinger I (2003) Gender difference in electrical brain activity during presentation of various film excerpts with different emotional content. Eur J Med Res 8, 192-198. |
| [15] | Dimpfel W, Schober F, Spüler M (1993) The influence of caffeine on human EEG under resting conditions and during mental loads. ClinInvestig 71, 197-207. |
| [16] | Siepmann M, Kirch W (2002) Effects of caffeine on topographic quantitative EEG. Neuropsychobiology 45, 161-6. |
| [17] | Barry RJ, Clarke AR, Johnstone SJ, Brown CR, Bruggemann JR, van Rijbroek I (2009) Caffeine effects on resting-state arousal in children. Int J Psychophysiol 73, 355-61. |
| [18] | Riekkinen P Jr, Sirviö J, Jäkälä P, Lammintausta R, Riekkinen P (1990) Effect of al-pha2 antagonists and an agonist on EEG slowing induced by scopolamine and lesion of the nucleus basa-lis.Neuropharmacology 11, 993-9. |
| [19] | Dimpfel W (2005) Pharmacological modulation of cholinergic brain activity and its reflection in special EEG frequency ranges from various brain areas in the freely moving rat (Tele-Stereo-EEG).EurNeuropsychopharmacol 15: 673-682. |
| [20] | Schellenberg R, Todorova A, Hofmann H.C, Dimpfel W, Schober F (1995) Differentiation of demented patients and healthy subjects by means of quantitative-topological EEG - a classification approach. Alzheimer's Research 1, 23–28. |
| [21] | Grunwald M, Weiss T, Krause W (1999) Power of theta waves in the EEG of human subjects increases during recall of haptic information. Neurosci Lett 260, 189-92. |
| [22] | Sauseng P, Klimesch W, Doppelmayr M, Hanslmayr S. Schabus M, Gruber WR (2004) Theta coupling in the human electroencephalogram during a working memory task. Neuroscience Letters 354, 123-126. |
| [23] | Bastiaanson MC, Oostenveld R, Jensen O, Hagoort P (2008) I see what you mean: theta power increases are involved in the retrieval of lexical semantic information. Brain Lang 106, 15-28. |
| [24] | Klimesch W (1999) EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res Brain Res Rev 29, 169-95. |
| [25] | Schellenberg R, Todorova A, Wedekind W, Schober F, Dimpfel W (1997) Pathophysiology and psychopharmacology of dementia – A new study design. 2. Cyclandelate Treatment – a Placebo-Controlled Double-Blind Clincal Trail. Neuropsychobiolgy 35, 132-142. |
| [26] | Deiber M-P, Ibanez V, Missonnier P, Herrmann F, Fazio-Costa L, Gold G, Giannakopoulos P (2009) Abnormal-induced theta activity supports early directed-attention network deficits in progressive MCI. Neurobiology of Ageing 30, 1444-52. |
| [27] | Dimpfel W 2014 Neurophysiological Biomarker of Mild Cognitive Impairment. Advances in Alzheimer`s Disease 3, No.2, June 2014, accepted. |
| [28] | Stomrud E, Hansson O, Minthon L, Blennow K, Rosen I, London E (2010) Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years. Neurobiol Aging 31, 215-223. |
| [29] | Fintelmann V, Grünwald J (2007) Efficacy and Tolerability of Rhodiola roseaExtractin Adults with Physical and Cognitive Deficiencies. Advances in Natural Therapy 24, 929-39. |
| [30] | Shevtsov VA, Zholus BI, Shervaly VI, Vol`skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G (2003) A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 10, 95-105. |
APA Style
Wilfried Dimpfel. (2014). Neurophysiological Effects of Rhodiola Rosea Extract Containing Capsules (A Double-Blind, Randomised, Placebo-Controlled Study). International Journal of Nutrition and Food Sciences, 3(3), 157-165. https://doi.org/10.11648/j.ijnfs.20140303.14
ACS Style
Wilfried Dimpfel. Neurophysiological Effects of Rhodiola Rosea Extract Containing Capsules (A Double-Blind, Randomised, Placebo-Controlled Study). Int. J. Nutr. Food Sci. 2014, 3(3), 157-165. doi: 10.11648/j.ijnfs.20140303.14
AMA Style
Wilfried Dimpfel. Neurophysiological Effects of Rhodiola Rosea Extract Containing Capsules (A Double-Blind, Randomised, Placebo-Controlled Study). Int J Nutr Food Sci. 2014;3(3):157-165. doi: 10.11648/j.ijnfs.20140303.14
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Download@article{10.11648/j.ijnfs.20140303.14,
author = {Wilfried Dimpfel},
title = {Neurophysiological Effects of Rhodiola Rosea Extract Containing Capsules (A Double-Blind, Randomised, Placebo-Controlled Study)},
journal = {International Journal of Nutrition and Food Sciences},
volume = {3},
number = {3},
pages = {157-165},
doi = {10.11648/j.ijnfs.20140303.14},
url = {https://doi.org/10.11648/j.ijnfs.20140303.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20140303.14},
abstract = {In 1947 Dr. Nicolai Lazarev introduced the term “adaptogen” in order to define special plant-derived extracts like Ginseng, which seemed to help to cope with stress-induced physical and psychic weakness. Extracts from Rhodiola rosea L. were recognized to belong to this category of food supplements. Due to contradictory results in the literature it was decided to examine the neurophysiological effect of Rhodiola rosea extract on surrogate parameters of cognitive and emotional brain processing in 20 volunteers. Spectral signatures of regional electric brain activity were recorded under control of an Eye-Tracking device, by means of which different challenges were presented. Among the cognitive challenges was a Stroop test, a memory test and a picture comparison for search of small deviations; among the emotional challenges were three pictures:a crying child, a bird spider and a picture taken from the TV series “Jungle Camp”. Additionally, three film excerpts were shown: a boring and an exciting animal film as well as a horror trailer. Evaluation of all challenges against looking at a fixation cross on the screen revealed highly statistically significant differences. These consisted (among others) in considerable higher spectral power values of delta and theta power in frontal and occipital brain areas during all cognitive and emotional tasks except for the crying child and bird spider, where only occipital power increased. Exactly these parameters changed in the presence of Rhodiola rosea extract, where increases of delta and theta power in these regions were documented in comparison to placebo. These statistically significant increases indicate mental activation according to literature. Likewise, an increase of alpha2 spectral power was observed during performance of the memory test indicating activation of memory processes as known from literature. In summary, the extract from Rhodiola rosea modulated cognitive and emotional surrogate parameters indicating improvement of mental processing in a stimulatory and activating sense.},
year = {2014}
}
TY - JOUR T1 - Neurophysiological Effects of Rhodiola Rosea Extract Containing Capsules (A Double-Blind, Randomised, Placebo-Controlled Study) AU - Wilfried Dimpfel Y1 - 2014/05/10 PY - 2014 N1 - https://doi.org/10.11648/j.ijnfs.20140303.14 DO - 10.11648/j.ijnfs.20140303.14 T2 - International Journal of Nutrition and Food Sciences JF - International Journal of Nutrition and Food Sciences JO - International Journal of Nutrition and Food Sciences SP - 157 EP - 165 PB - Science Publishing Group SN - 2327-2716 UR - https://doi.org/10.11648/j.ijnfs.20140303.14 AB - In 1947 Dr. Nicolai Lazarev introduced the term “adaptogen” in order to define special plant-derived extracts like Ginseng, which seemed to help to cope with stress-induced physical and psychic weakness. Extracts from Rhodiola rosea L. were recognized to belong to this category of food supplements. Due to contradictory results in the literature it was decided to examine the neurophysiological effect of Rhodiola rosea extract on surrogate parameters of cognitive and emotional brain processing in 20 volunteers. Spectral signatures of regional electric brain activity were recorded under control of an Eye-Tracking device, by means of which different challenges were presented. Among the cognitive challenges was a Stroop test, a memory test and a picture comparison for search of small deviations; among the emotional challenges were three pictures:a crying child, a bird spider and a picture taken from the TV series “Jungle Camp”. Additionally, three film excerpts were shown: a boring and an exciting animal film as well as a horror trailer. Evaluation of all challenges against looking at a fixation cross on the screen revealed highly statistically significant differences. These consisted (among others) in considerable higher spectral power values of delta and theta power in frontal and occipital brain areas during all cognitive and emotional tasks except for the crying child and bird spider, where only occipital power increased. Exactly these parameters changed in the presence of Rhodiola rosea extract, where increases of delta and theta power in these regions were documented in comparison to placebo. These statistically significant increases indicate mental activation according to literature. Likewise, an increase of alpha2 spectral power was observed during performance of the memory test indicating activation of memory processes as known from literature. In summary, the extract from Rhodiola rosea modulated cognitive and emotional surrogate parameters indicating improvement of mental processing in a stimulatory and activating sense. VL - 3 IS - 3 ER -
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