The Effect of Saffron (<i>Crocus sativus L. Iridaceae</i>) Orally Administration on Blood Level of Sex Hormones in Rats

Babaev Khanaga Fizuli; Shukurova Parvana Agababa; Ibragimov Anar Shamistan; Abbasov Ragif Yusub; Ibragimova Jale Muchtar; Alieva Ravana Iqbal; Gasimova Gulnara Zair

doi:doi:10.11648/j.jdmp.20220802.11

The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats

Babaev Khanaga Fizuli, Shukurova Parvana Agababa, Ibragimov Anar Shamistan, Abbasov Ragif Yusub, Ibragimova Jale Muchtar, Alieva Ravana Iqbal, Gasimova Gulnara Zair

Published in Journal of Diseases and Medicinal Plants (Volume 8, Issue 2)

Received: 20 February 2022 Accepted: 15 March 2022 Published: 14 April 2022

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Abstract

Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.

Published in	Journal of Diseases and Medicinal Plants (Volume 8, Issue 2)
DOI	10.11648/j.jdmp.20220802.11
Page(s)	24-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Saffron Extract, Female Rats, Follicle-Stimulating Hormone, Male Rats, Testosterone, Phytoprotector

References

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[3]	Mustafina O. E., Somova R. Sh. (2015) SOME RESULTS OF MOLECULAR GENETIC RESEARCHES OF AGING AND LONGEVITY. Аdvances in gerontology. 28 (1): 11–26.
[4]	ANDREEVA E. N., SHEREMETYEVA E. V., GRIGORYAN O. R. (2020) Environmental factors and menopause. Russian Journal of Human Reproduction 26 (4): 14-21.
[5]	Wu D., Gore A. C. (2010) Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats. Norm. Behav. 58 (2): 306-316.
[6]	Minici F., Tiberi F., Tropea A. et al. (2007) Paracrine regulation of endometriotic tissue. Gynecol. Endocr. 23. (10): 574–580.
[7]	WHO monographs on medicinal plants, Widely used in the Newly Independent States (2010) World Health Organization: 464.
[8]	Salahshoor M. R., Khazaei M., Jalili C., Keivan M. Crocin Improves Damage Induced by Nicotine on A Number of Reproductive Parameters in Male Mice (2016) International Journal of Fertility and Sterility 10 (1): 71-78.
[9]	Khayatnouri M., Safavi S. E., Safarmashaei S., Babazadeh D., Mikailpourardabili B. (2011) The effect of Saffron Orally Administration on Spermatogenesis Index in Rat. Advances in Environmental Biology, 5 (7): 1514-1521.
[10]	Shamsa A., Hosseinzadeh H., Molaei M. et al. 2009 Evaluation of Crocus sativus L. (saffron) on male erectile dysfunction: a pilot study. Phytomedicine 8 (16): 690-693.
[11]	Hosseinzadeh H., Zeall T., Sadeghi A. (2008) The effect of saffron, Crocus sativus stigma, extract and its constituents safranal and crocin on sexual behaviors in normal male rats. Phytomedicine 15 (6-7): 491-495.
[12]	Modaresi M. Messripour M., AsadiMarghmaleki M. et al. (2008) Effect of saffron (Сrocus sativus) extract on level of FSH, LH and testosterone in mice. ZUMS Journal 16 (63): 11-18.
[13]	Ai J., Nekooeian A. A., Takhshid M. A., Mostafizi N. et al. (2009) Effect of Aqueous Extract of Crocus sativus L. (Saffron) Stigma on Serum Levels of Gonadotropins and Folliculogenesis in Adult Rats. Journal of Applied Animal Research 35: 49-52.
[14]	Agha-Hosseini M., Kashani L., Aleyaseen A. et al. (2008) Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomized and placebo-controlled trial. BJOG 115 (4): 515-519.
[15]	Abdullayev F. I. (1993) Biological effects of saffron. J. BioFactors 4: 83-86.
[16]	Akhondzadeh S., Fallah-Pour H., Afkham K. et al. (2004) Comparison of Crocus sativus L. and imipramine in the treatment on mild of moderate depression: a pilot double-blind randomized trial [ISRCT N 45683816] // BMC Complement Altern. Med. 2: 6771.
[17]	Georgiadou G, Tarantilis PA, Pitsikas N. (2012) Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder. NeurosciLett. 528 (1): 27-30.
[18]	Hashimova U. F., Babaev Kh. F., Sadykh-zade R. A., Shukurova P. A. (2016) Potential anti-aging properties of saffron (Crocus sativus, L.) Vrach 6: 35-38.
[19]	Verma SK, Bordia A. (1998) Antioxidant property of Saffron in man Indian J. Med. Sci. 52. (5): 205-207.

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APA Style

Babaev Khanaga Fizuli, Shukurova Parvana Agababa, Ibragimov Anar Shamistan, Abbasov Ragif Yusub, Ibragimova Jale Muchtar, et al. (2022). The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. Journal of Diseases and Medicinal Plants, 8(2), 24-27. https://doi.org/10.11648/j.jdmp.20220802.11

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ACS Style

Babaev Khanaga Fizuli; Shukurova Parvana Agababa; Ibragimov Anar Shamistan; Abbasov Ragif Yusub; Ibragimova Jale Muchtar, et al. The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. J. Dis. Med. Plants 2022, 8(2), 24-27. doi: 10.11648/j.jdmp.20220802.11

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AMA Style

Babaev Khanaga Fizuli, Shukurova Parvana Agababa, Ibragimov Anar Shamistan, Abbasov Ragif Yusub, Ibragimova Jale Muchtar, et al. The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. J Dis Med Plants. 2022;8(2):24-27. doi: 10.11648/j.jdmp.20220802.11

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@article{10.11648/j.jdmp.20220802.11,
  author = {Babaev Khanaga Fizuli and Shukurova Parvana Agababa and Ibragimov Anar Shamistan and Abbasov Ragif Yusub and Ibragimova Jale Muchtar and Alieva Ravana Iqbal and Gasimova Gulnara Zair},
  title = {The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {8},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.jdmp.20220802.11},
  url = {https://doi.org/10.11648/j.jdmp.20220802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20220802.11},
  abstract = {Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.},
 year = {2022}
}

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TY  - JOUR
T1  - The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats
AU  - Babaev Khanaga Fizuli
AU  - Shukurova Parvana Agababa
AU  - Ibragimov Anar Shamistan
AU  - Abbasov Ragif Yusub
AU  - Ibragimova Jale Muchtar
AU  - Alieva Ravana Iqbal
AU  - Gasimova Gulnara Zair
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.jdmp.20220802.11
DO  - 10.11648/j.jdmp.20220802.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 24
EP  - 27
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20220802.11
AB  - Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.
VL  - 8
IS  - 2
ER  -

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Author Information

Babaev Khanaga Fizuli

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan
Shukurova Parvana Agababa

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan
Ibragimov Anar Shamistan

Department of Biology, Khazar University, Baku, Republic of Azerbaijan
Abbasov Ragif Yusub

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan
Ibragimova Jale Muchtar

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan
Alieva Ravana Iqbal

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan
Gasimova Gulnara Zair

Institute of Physiology Named After A. I. Karaev, Azerbaijan National Academy of Sciences, Baku, Republic of Azerbaijan

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APA Style

Babaev Khanaga Fizuli, Shukurova Parvana Agababa, Ibragimov Anar Shamistan, Abbasov Ragif Yusub, Ibragimova Jale Muchtar, et al. (2022). The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. Journal of Diseases and Medicinal Plants, 8(2), 24-27. https://doi.org/10.11648/j.jdmp.20220802.11

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ACS Style

Babaev Khanaga Fizuli; Shukurova Parvana Agababa; Ibragimov Anar Shamistan; Abbasov Ragif Yusub; Ibragimova Jale Muchtar, et al. The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. J. Dis. Med. Plants 2022, 8(2), 24-27. doi: 10.11648/j.jdmp.20220802.11

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AMA Style

Babaev Khanaga Fizuli, Shukurova Parvana Agababa, Ibragimov Anar Shamistan, Abbasov Ragif Yusub, Ibragimova Jale Muchtar, et al. The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats. J Dis Med Plants. 2022;8(2):24-27. doi: 10.11648/j.jdmp.20220802.11

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@article{10.11648/j.jdmp.20220802.11,
  author = {Babaev Khanaga Fizuli and Shukurova Parvana Agababa and Ibragimov Anar Shamistan and Abbasov Ragif Yusub and Ibragimova Jale Muchtar and Alieva Ravana Iqbal and Gasimova Gulnara Zair},
  title = {The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {8},
  number = {2},
  pages = {24-27},
  doi = {10.11648/j.jdmp.20220802.11},
  url = {https://doi.org/10.11648/j.jdmp.20220802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20220802.11},
  abstract = {Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.},
 year = {2022}
}

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TY  - JOUR
T1  - The Effect of Saffron (Crocus sativus L. Iridaceae) Orally Administration on Blood Level of Sex Hormones in Rats
AU  - Babaev Khanaga Fizuli
AU  - Shukurova Parvana Agababa
AU  - Ibragimov Anar Shamistan
AU  - Abbasov Ragif Yusub
AU  - Ibragimova Jale Muchtar
AU  - Alieva Ravana Iqbal
AU  - Gasimova Gulnara Zair
Y1  - 2022/04/14
PY  - 2022
N1  - https://doi.org/10.11648/j.jdmp.20220802.11
DO  - 10.11648/j.jdmp.20220802.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 24
EP  - 27
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20220802.11
AB  - Modern medicine is currently marked by an increased interest in herbal pharmaceutical drugs traditionally applied in folk medicine in a significant number of diseases. In this regard, saffron (Crocus sativus L. Iridaceae) is of particular importance. This paper presents the results of study of the effects of Azerbaijan-grown saffron on blood level of follicle-stimulating hormone (FSH) in female rats, as well as on blood level of testosterone in male rats. In the blood serums of animals, using hormonal test systems for enzyme immunoassay, FSH and testosterone levels were determined. The findings revealed a decrease in blood levels of FSH in 12-month-old female rats as compared to the control group (comprising animals of the same age which did not receive the saffron extract), as they approximated the registered levels of 6-month-old female rats. Saffron increased the blood level of testosterone as compared to untreated controls, which did not receive saffron. Saffron’s unique medicinal properties largely owe to the diversity of biologically active substances it contains The effects of saffron treatment observed in the course of this study could be explained by the direct impact of saffron and its components on the sex glands and the central nervous system. Findings of diverse pharmacological effects of the saffron extract open new horizons for the development of scientifically corroborated recommendations for application in practical medicine.
VL  - 8
IS  - 2
ER  -

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