Although different combinations of nutrition interventions are employed, most are insufficient to reduce stunting significantly. This study aimed to draw current evidence to reduce stunting among under 5 years children from randomized controlled trials. Eligible randomized controlled trials met inclusion criteria were included. The weighted mean effect sizes with 95% CIs were used as summary measures for changes in height-for-age z score (HAZ) using random-effect models; heterogeneity was analyzed using predefined characteristics. From the total of 116 articles, 47 randomized controlled trials with a sample size of 35,115 study participants were included for analysis. Except for educational intervention (0.14; 95%CI: 0.00, 0.27), the weighted mean effects of iron, zinc, water, sanitation and hygiene (WASH), multiple micronutrients (MMN) and dietary interventions were all insignificant. A fixed combination of nutrition interventions demonstrating similar benefit in all contexts is not found. Our results are insufficient to make a recommendation on the most appropriate interventions to reduce stunting in all settings. This result highlights the importance of further evidence before nutrition component formulation for large-scale interventions. The short duration of the interventions and lack of information about the infection status of participants in most of the included trials remain two of the possible limitations needing consideration.
Published in | Journal of Food and Nutrition Sciences (Volume 9, Issue 3) |
DOI | 10.11648/j.jfns.20210903.12 |
Page(s) | 73-83 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Evidence, Iron, Meta-analysis, Nutrition Education, Sanitation, Stunting, Zinc
[1] | Bhutta ZA, Das JK, RizviA, et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? The Lancet, 2013382 (9890): 452–477. |
[2] | Prado EL, Yakes Jimenez E, Vosti S, et al. (2019) Path analyses of risk factors for linear growth faltering in four prospective cohorts of young children in Ghana, Malawi, and Burkina Faso. BMJ Global Health, 2019. 4 (1): 1–11. |
[3] | Lundeen EA, Behrman JR, Crookston BT, et al. Growth faltering and recovery in children aged 1-8 years in four low- and middle-income countries: Young Lives. Public Health Nutrition 2014, 17 (9): 2131–2137. |
[4] | World Health Organization. Reducing stunting in children: equity considerations for achieving the Global Nutrition Targets 2025.2018. WHO. Geneva. |
[5] | Federal Democratic Republic of Ethiopia. The ‘Seqota’ declaration implementation plan (2016-2030); summary of programme approach document. 2016. Federal Democratic Republic of Ethiopia. Adiss Ababa. |
[6] | Bush A and Keylock J. Strengthening integration of nutrition within health sector programmes an evidence-based planning resource. European commission directorate general international cooperation and development. 2018. Brussels. |
[7] | Bhandari N, Bahl R and TanejaS. Effect of micronutrient supplementation on linear growth of children. British Journal of Nutrition, 2001; 85 (S2): S131. |
[8] | Prendergast AJ and Humphrey JH. The stunting syndrome in developing countries. Paediatrics and International Child Health, 2014; 34 (4): 250–265. |
[9] | Bhutta ZA, Ahmed T, Black RE, et al. What works? Interventions for maternal and child undernutritionand survival. The Lancet, 2008; 371 (9610): 417–440. |
[10] | deOnis M and Branca F. Childhood stunting: a global perspective. Maternal & Child Nutrition, 2016; 12: 12–26. |
[11] | Horton S, Shekar M. and Ajay M. Scaling Up Nutrition. 2009. The World Bank. doi: 10.1596/978-0-8213-8077-2. |
[12] | Reinhardt K and Fanzo J. Addressing chronic malnutrition through multi-sectoral sustainable approaches : a review of the causes and consequences. Frontiers in nutrition, 2014; 1 (13): 1–11. |
[13] | Mabhaudhi T, Chibarabada Tand Modi A. Water-food-nutrition-health nexus : Linking water to improving food, nutrition and health in sub-saharan Africa. Int. J. Environ. Res. And Public Health, 2016; 13 (107): 1–19. |
[14] | Mohammed SH, Habtewold TD, Tegegne BS, et al. Dietary and non-dietary determinants of linear growth status of infants and young children in Ethiopia: Hierarchical regression analysis. PLOS ONE, 2019; 14 (1): e0209220. |
[15] | de Onis M, Dewey KG, Borghi E, et al. The World Health Organization’s global target for reducing childhood stunting by 2025: rationale and proposed actions. Maternal & Child Nutrition, 2013; 9 (2): 6–26. |
[16] | FAO, UNICEF, IFAD, WFP, WHO. The State of Food Security and Nutrition in the World. Safeguarding against economic slowdowns and downturns. 2019. Rome. |
[17] | Hossain M, Choudhury N, Adib Binte Abdullah K, et al. Evidence-based approaches to childhood stunting in low and middle income countries: a systematic review. Archives of Disease in Childhood, 2017; 102 (10): 903–909. |
[18] | Gillespie S, Menon P, Heidkamp R, et al. Measuring the coverage of nutrition interventions along the continuum of care: time to act at scale, BMJ Global Health, 2019; 4 (Suppl 4): e001290. |
[19] | Black RE, Allen LH, Bhutta ZA, et al. Maternal and child undernutrition: global and regional exposures and health consequences. The Lancet, 2008; 371 (9608): 243–260. |
[20] | Keenan JD, Gebresillasie S, Stoller NE, et al. Linear growth in preschool children treated with mass azithromycin distributions for trachoma : a cluster-randomized trial. PLOS ONE, 2019; neglected tropial diseases 13 (6): 1–12. |
[21] | Fenn B, Bulti AT, Nduna T, et al. An evaluation of an operations research project to reduce childhood stunting in a food-insecure area in Ethiopia. Public Health Nutrition, 2012; 15 (9): 1746–1754. |
[22] | Pridmore P and Hill RC. Addressing the underlying and basic causes of child undernutrition in developing countries: What works and why?’. Evaluation study, ministry of foreign affairs of Denmark, 2009; (2): 1-97. |
[23] | Moher D, Liberati A, Tetzlaff J, et al. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Medicine, 2009; 6 (7): e1000097. |
[24] | Evans N, Lasen M and Tsey K (2015) Effective Public Health Practice Project (EPHPP) Quality Assessment Tool for Quantitative Studies. 2015. Springer International Publishing: Springer Briefs in Public Health, 2015; 45-63. DOI 10.1007/978-3-319-17284-2 |
[25] | Higgins, J. P. and Green, S. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane Handbook for Systematic Reviews of Interventions: 2008. Cochrane Book Series. Edited by J. P. Higgins and S. Green. Chichester, UK: John Wiley & Sons, Ltd. doi: 10.1002/9780470712184. |
[26] | EggerM, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test measures of funnel plot asymmetry. BMJ, 1997; 315 (7109): 629–34. |
[27] | Sachdev H, Gera T and Nestel P. Effect of iron supplementation on physical growth in children: systematic review of randomised controlled trials. Public Health Nutrition, 2006; 9 (7): 904–920. |
[28] | Dossa R, Ategbo E, de Koning F, et al. Impact of iron supplementation and deworming on growth performance in preschool Beninese children. European Journal of Clinical Nutrition, 2001; 55 (4): 223-228. |
[29] | Pickering AJ, Djebbari H, Lopez C, et al. Effect of a community-led sanitation intervention on child diarrhoea and child growth in rural Mali: a cluster-randomised controlled trial. The Lancet Global Health, 2015; 3 (11): e701–e711. |
[30] | Hop LT and Berger J. Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: Double-blind, randomized, placebo-controlled trial. The Journal of Nutrition, 2005; 135 (3): 660S-665S. |
[31] | Alarcon K, Kolsteren PW, Prada AM, et al. Effects of separate delivery of zinc or zinc and vitamin A on hemoglobin response, growth, and diarrhea in young Peruvian children receiving iron therapy for anemia. Am J Clin Nutr, 2004; 80 (5): 1276–1282. |
[32] | Lopriore C, Guidoum Y, Briend A, et al. (2004) Spread fortified with vitamins and minerals induces catch-up growth and eradicates severe anemia in stunted refugee children aged, Am J Clin Nutr, 2004; 80: 973–981. |
[33] | Waswa LM, Jordan I, Herrmann J, et al. Community-based educational intervention improved the diversity of complementary diets in western Kenya : results from a randomized controlled trial. Public Health Nutrition, 2015; 18 (18): 3406–3419. |
[34] | Soliman AT, Al dabbagh MM, Habboub AH, et al. Linear growth in children with iron deficiency anemia before and after treatment. Journal of Tropical Pediatrics, 2009; 55 (5): 324–327. |
[35] | Perng W, Mora-Plazas M, Marin C, et al. Iron status and linear growth: a prospective study in school-Age children. European J Clin Nutr, 2013; 67 (6): 646–651. |
[36] | Ramakrishnan U, Nguyen P and Martorell R. Effects of micronutrients on growth of children under 5 y of age : meta-analyses of single and multiple nutrient interventions. Am J Clin Nutr, 2009; 89: 191–203. |
[37] | MacDonald RS. The role of zinc in growth and cell proliferation, The Journal of Nutrition, 2000; 130 (5): 1500S-1508S. |
[38] | Vucic V, Berti C, Vollhardt C, et al. Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis. Nutrition Reviews, 2013; 71 (6): 386–401. |
[39] | Pasricha SR, Hayes E, Kalumba K, et al. Effect of daily iron supplementation on health in children aged 4-23 months: A systematic review and meta-analysis of randomised controlled trials. The Lancet Global Health, 2013; 1 (2): e77–e86. |
[40] | Smuts CM, Dhansay MA, Faber M, et al. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants. The Journal of Nutrition, 2005; 135 (3): 653S-659S. |
[41] | Dewey KG, Domello M, Cohen RJ, et al. Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J. Nutr, 2002; 132: 3249-3255. |
[42] | Untoro J, Karyadi E, Wibowo L, et al. Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, double-blind, placebo-controlled trial. J. Nutr, 2005; 135: 639–645. |
[43] | Majumdar I, Paul P, Talib VH, et al. The effect of iron therapy on the growth of iron-replete and iron-deplete children. Journal of Tropical Pediatrics, 2003; 49 (2): 84–88. |
[44] | Thompson J, Biggs BA and Pasricha SR. Effects of daily iron supplementation in 2 to 5-year-old children: systematic review and meta-analysis. Pediatrics, 2013; 131 (4): 739–753. |
[45] | Brown KH. Zinc and child growth: Commentary. International Journal of Epidemiology, 2003; 32 (6): 1103–1104. |
[46] | Osredkar, J. Copper and zinc, biological role and significance of copper/zinc imbalance. Journal of Clinical Toxicology, 2011; s3 (01): 1–18. |
[47] | Imdad A and Bhutta ZA. Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries. BMC Public Health, 2011; 11 (3): 377 |
[48] | Das JK, Kumar R, Salam RA and Bhutta ZA. Systematic review of zinc fortification trials. Annals of Nutrition and Metabolism, 2013; 62 (s1): 44–56. |
[49] | Adu-Afarwuah S, Lartey A, Brown KH, et al. Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development. Am J Clin Nutr, 2007; 86 (2): 412–420. |
[50] | Masuda K and Chitundu M. Multiple micronutrient supplementation using spirulinaplatensis and infant growth, morbidity, and motor development: Evidence from a randomized trial in Zambia. PLOS ONE, 2019; 14 (2): e0211693. |
[51] | Oelofse A, Van Raaij JMA, Benade AJS, et al. The effect of a micronutrient-fortified complementary food on micronutrient status, growth and development of 6- to 12-month-old disadvantaged urban South African infants. International Journal of Food Sciences and Nutrition, 2003; 54 (5): 399–407. |
[52] | Shafique S, Sellen DW, Lou W, et al. Mineral- and vitamin-enhanced micronutrient powder reduces stunting in full-term low-birth-weight infants receiving nutrition, health, and hygiene education : a cluster-randomized trial. Am J Clin Nutr, 2016; 103, p. 1357–69. |
[53] | Onyango AW, Borghi E, de Onis M, et al. Complementary feeding and attained linear growth among 6-23-month-old children. Public Health Nutrition, 2014; 17 (9): 1975–1983. |
[54] | Dangour AD, Watson L, Cumming O, et al. Interventions to improve water quality and supply, sanitation and hygiene practices, and their effects on the nutritional status of children. 2013, Cochrane Database of Systematic Reviews, (8). doi: 10.1002/14651858.CD009382.pub2. |
[55] | Rah JH, Cronin AA, Badgaiyan B, et al. Household sanitation and personal hygiene practices are associated with child stunting in rural India: a cross-sectional analysis of surveys. BMJ Open, 2015; 5 (2): 1–10. |
[56] | Ngure FM, Reid BM, Humphrey JH, et al. Water, sanitation, and hygiene (WASH), environmental enteropathy, nutrition, and early child development: Making the links. Annals of the New York Academy of Sciences, 2014; 1308 (1): 118–128. |
APA Style
Zelalem Tafese, Yifru Berhan. (2021). Current Evidence for Nutrition Intervention: A Meta-analysis. Journal of Food and Nutrition Sciences, 9(3), 73-83. https://doi.org/10.11648/j.jfns.20210903.12
ACS Style
Zelalem Tafese; Yifru Berhan. Current Evidence for Nutrition Intervention: A Meta-analysis. J. Food Nutr. Sci. 2021, 9(3), 73-83. doi: 10.11648/j.jfns.20210903.12
AMA Style
Zelalem Tafese, Yifru Berhan. Current Evidence for Nutrition Intervention: A Meta-analysis. J Food Nutr Sci. 2021;9(3):73-83. doi: 10.11648/j.jfns.20210903.12
@article{10.11648/j.jfns.20210903.12, author = {Zelalem Tafese and Yifru Berhan}, title = {Current Evidence for Nutrition Intervention: A Meta-analysis}, journal = {Journal of Food and Nutrition Sciences}, volume = {9}, number = {3}, pages = {73-83}, doi = {10.11648/j.jfns.20210903.12}, url = {https://doi.org/10.11648/j.jfns.20210903.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20210903.12}, abstract = {Although different combinations of nutrition interventions are employed, most are insufficient to reduce stunting significantly. This study aimed to draw current evidence to reduce stunting among under 5 years children from randomized controlled trials. Eligible randomized controlled trials met inclusion criteria were included. The weighted mean effect sizes with 95% CIs were used as summary measures for changes in height-for-age z score (HAZ) using random-effect models; heterogeneity was analyzed using predefined characteristics. From the total of 116 articles, 47 randomized controlled trials with a sample size of 35,115 study participants were included for analysis. Except for educational intervention (0.14; 95%CI: 0.00, 0.27), the weighted mean effects of iron, zinc, water, sanitation and hygiene (WASH), multiple micronutrients (MMN) and dietary interventions were all insignificant. A fixed combination of nutrition interventions demonstrating similar benefit in all contexts is not found. Our results are insufficient to make a recommendation on the most appropriate interventions to reduce stunting in all settings. This result highlights the importance of further evidence before nutrition component formulation for large-scale interventions. The short duration of the interventions and lack of information about the infection status of participants in most of the included trials remain two of the possible limitations needing consideration.}, year = {2021} }
TY - JOUR T1 - Current Evidence for Nutrition Intervention: A Meta-analysis AU - Zelalem Tafese AU - Yifru Berhan Y1 - 2021/06/07 PY - 2021 N1 - https://doi.org/10.11648/j.jfns.20210903.12 DO - 10.11648/j.jfns.20210903.12 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 73 EP - 83 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20210903.12 AB - Although different combinations of nutrition interventions are employed, most are insufficient to reduce stunting significantly. This study aimed to draw current evidence to reduce stunting among under 5 years children from randomized controlled trials. Eligible randomized controlled trials met inclusion criteria were included. The weighted mean effect sizes with 95% CIs were used as summary measures for changes in height-for-age z score (HAZ) using random-effect models; heterogeneity was analyzed using predefined characteristics. From the total of 116 articles, 47 randomized controlled trials with a sample size of 35,115 study participants were included for analysis. Except for educational intervention (0.14; 95%CI: 0.00, 0.27), the weighted mean effects of iron, zinc, water, sanitation and hygiene (WASH), multiple micronutrients (MMN) and dietary interventions were all insignificant. A fixed combination of nutrition interventions demonstrating similar benefit in all contexts is not found. Our results are insufficient to make a recommendation on the most appropriate interventions to reduce stunting in all settings. This result highlights the importance of further evidence before nutrition component formulation for large-scale interventions. The short duration of the interventions and lack of information about the infection status of participants in most of the included trials remain two of the possible limitations needing consideration. VL - 9 IS - 3 ER -