Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients

Kamilia Guedri; Aziez Chettoum; Nawel Attoui

doi:doi:10.11648/j.jher.20190501.14

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Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients

Kamilia Guedri, Aziez Chettoum, Nawel Attoui

Published in Journal of Health and Environmental Research (Volume 5, Issue 1)

Received: 22 January 2019 Accepted: 6 March 2019 Published: 21 March 2019

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Abstract

Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.

Published in	Journal of Health and Environmental Research (Volume 5, Issue 1)
DOI	10.11648/j.jher.20190501.14
Page(s)	24-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Sofosbuvir, Ribavirin, Pegylated Interferon, Hepatitis C, Hematological Toxicity

References

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APA Style

Kamilia Guedri, Aziez Chettoum, Nawel Attoui. (2019). Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. Journal of Health and Environmental Research, 5(1), 24-31. https://doi.org/10.11648/j.jher.20190501.14

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ACS Style

Kamilia Guedri; Aziez Chettoum; Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J. Health Environ. Res. 2019, 5(1), 24-31. doi: 10.11648/j.jher.20190501.14

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AMA Style

Kamilia Guedri, Aziez Chettoum, Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J Health Environ Res. 2019;5(1):24-31. doi: 10.11648/j.jher.20190501.14

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@article{10.11648/j.jher.20190501.14,
  author = {Kamilia Guedri and Aziez Chettoum and Nawel Attoui},
  title = {Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients},
  journal = {Journal of Health and Environmental Research},
  volume = {5},
  number = {1},
  pages = {24-31},
  doi = {10.11648/j.jher.20190501.14},
  url = {https://doi.org/10.11648/j.jher.20190501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jher.20190501.14},
  abstract = {Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.},
 year = {2019}
}

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TY  - JOUR
T1  - Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients
AU  - Kamilia Guedri
AU  - Aziez Chettoum
AU  - Nawel Attoui
Y1  - 2019/03/21
PY  - 2019
N1  - https://doi.org/10.11648/j.jher.20190501.14
DO  - 10.11648/j.jher.20190501.14
T2  - Journal of Health and Environmental Research
JF  - Journal of Health and Environmental Research
JO  - Journal of Health and Environmental Research
SP  - 24
EP  - 31
PB  - Science Publishing Group
SN  - 2472-3592
UR  - https://doi.org/10.11648/j.jher.20190501.14
AB  - Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.
VL  - 5
IS  - 1
ER  -

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Author Information

Kamilia Guedri

Department of Biology, University Larbi Tebessi, Tebessa, Algeria
Aziez Chettoum

Department of Biology Animal, University Mentouri, Constantine, Algeria
Nawel Attoui

Department of Biology, University Tahri Mohamed, Bechar, Algeria

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Kamilia Guedri, Aziez Chettoum, Nawel Attoui. (2019). Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. Journal of Health and Environmental Research, 5(1), 24-31. https://doi.org/10.11648/j.jher.20190501.14

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ACS Style

Kamilia Guedri; Aziez Chettoum; Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J. Health Environ. Res. 2019, 5(1), 24-31. doi: 10.11648/j.jher.20190501.14

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AMA Style

Kamilia Guedri, Aziez Chettoum, Nawel Attoui. Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients. J Health Environ Res. 2019;5(1):24-31. doi: 10.11648/j.jher.20190501.14

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@article{10.11648/j.jher.20190501.14,
  author = {Kamilia Guedri and Aziez Chettoum and Nawel Attoui},
  title = {Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients},
  journal = {Journal of Health and Environmental Research},
  volume = {5},
  number = {1},
  pages = {24-31},
  doi = {10.11648/j.jher.20190501.14},
  url = {https://doi.org/10.11648/j.jher.20190501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jher.20190501.14},
  abstract = {Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.},
 year = {2019}
}

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TY  - JOUR
T1  - Comparative Study of Hematological Disorders of Antiviral Treatments in Algerian Chronic Hepatitis C Patients
AU  - Kamilia Guedri
AU  - Aziez Chettoum
AU  - Nawel Attoui
Y1  - 2019/03/21
PY  - 2019
N1  - https://doi.org/10.11648/j.jher.20190501.14
DO  - 10.11648/j.jher.20190501.14
T2  - Journal of Health and Environmental Research
JF  - Journal of Health and Environmental Research
JO  - Journal of Health and Environmental Research
SP  - 24
EP  - 31
PB  - Science Publishing Group
SN  - 2472-3592
UR  - https://doi.org/10.11648/j.jher.20190501.14
AB  - Viral hepatitis C (HCV) is a major health problem that affects important number of people around the world, the emergence of new direct antiviral treatments is a real therapeutic revolution to days it allows the cure hepatitis C in the majority of patients, but these treatments is accompanied by numerous side effects. Sofosbuvir, Pegylated interferon and Ribavirin are the standard care for the treatment of chronic hepatitis C in Algeria. In this study, we are interesting to investigate hematological toxicity of Antiviral treatment in Algerian patients with chronic hepatitis C. We carried out a comparative study, which involved 300 men and women Algerian at different ages. The determination of the various Epidemiological, Hematological, biochemical (AST, ALT, Glycemia) and virological (Viral load) parameters was performed. The analysis of 300 data shows that the infection with hepatitis C affects the age group between (46 - 65 years) with a percentage of 67% with a female predominance 82% and a clear predominance of genotype 1b with a percentage (89%), Dual therapy (Sofosbuvir + Ribavirin) and triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) induce a high hematological toxicity - Hemolytic anemia ( revealed by a decrease of the number of Red blood cell and Hemoglobin level, as well as the percentage of hematocrit and the increase of mean corpuscular volume that induced the increase of red blood cell masse and the expansion) - Thrombocytopenia (revealed by the decrease in the number of platelets ) and leukopenia (translated by the decrease in the number of White blood cells and lymphocytes as well as monocytes, and a very significant increase in granulocytes) whereas in monotherapy (Sofosbuvir) a low toxicity was noticed, the Patients how receiving triple therapy (Sofosbuvir + Ribavirin + Pegylated interferon) can be developing diabetes mellitus. Antiviral treatments were significantly induced hemolytic anemia, leucopenia and thrombopenia in Algerian patients with chronic hepatitis C.
VL  - 5
IS  - 1
ER  -

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