Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia

Tesfaye Taye Gelaw; Amha Mekasha Wondemagegn

doi:doi:10.11648/j.sjcm.20130206.16

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Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia

Tesfaye Taye Gelaw, Amha Mekasha Wondemagegn

Published in Science Journal of Clinical Medicine (Volume 2, Issue 6)

Received: 22 October 2013 Published: 20 November 2013

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Abstract

Background: The aim of this study was to describe the response to nutritional treatment of severely malnourished hospitalized children in relation to HIV infection Methods: The study was conducted in the paediatric wards of Yekatit 12 hospital, which is situated in Addis Ababa, Ethiopia serving as a referral hospital for clinics, health centers and hospitals situated in and out of Addis Ababa. It also serves as a teaching hospital for AAU Medical students and Residents. We studied 300 severely malnourished children (presence of oedema, weight for age < 60% on HC and/ or weight-for-height <70%). At admission, HIV serology was confirmed by ELISA, for children >18 months of age, and PCR (DBS) was performed for those <18 months and CD4+ cells were measured for those who turned out to be positive. Complete blood count (CBC), including differential counts, was determined using a Coulter counter and/or manually. The study is a prospective observational analytic cohort study. Result: Of the 300 children, 75 were HIV Positive (cases) and the remaining 225 were controls (1:3 ratio). There was no significant difference by sex, age group, site of residency, family in come, family educational status, medical illness, hematologic profiles, immune category and presence or absence of edema in the treatment out come of HIV infected children compared to uninfected once. Among HIV infected forty three (43/75) failed to respond to the nutritional intervention when compared to those who are not infected (225/38) (Adjusted OR = 6.61, 95%CI = 0.053, 0.423). Conclusion: HIV infection is a major challenge in addressing nutritional intervention for those children who are severely malnourished admitted in Yekatit 12 hospital. An intervention to alleviate the challenge in managing the problem has to be designed based on further interventional studies.

Published in	Science Journal of Clinical Medicine (Volume 2, Issue 6)
DOI	10.11648/j.sjcm.20130206.16
Page(s)	176-182
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

HIV, Malnutrition, Treatment Response

References

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[13]	NI Paton, S Sangeetha, A Earnest and R Bellamy; The impact of malnutrition on survival & the CD4 count response in HIV-infected Patients starting ART; HIV Medicine 2006, 7, 323–330
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[19]	Buford Nichols; Treatment of severe malnutrition in developing countries, Uptodate version 15.3
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[22]	Michael Golden; The management of severe acute malnutrition; A manual for Ethiopia; UNICEF, 2002.
[23]	Fawzi WW, Msamanga GI, Spiegelman D et al. (2004) "Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality" New England Journal of Medicine 351:23-32.
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APA Style

Tesfaye Taye Gelaw, Amha Mekasha Wondemagegn. (2013). Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Science Journal of Clinical Medicine, 2(6), 176-182. https://doi.org/10.11648/j.sjcm.20130206.16

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ACS Style

Tesfaye Taye Gelaw; Amha Mekasha Wondemagegn. Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Sci. J. Clin. Med. 2013, 2(6), 176-182. doi: 10.11648/j.sjcm.20130206.16

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AMA Style

Tesfaye Taye Gelaw, Amha Mekasha Wondemagegn. Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Sci J Clin Med. 2013;2(6):176-182. doi: 10.11648/j.sjcm.20130206.16

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@article{10.11648/j.sjcm.20130206.16,
  author = {Tesfaye Taye Gelaw and Amha Mekasha Wondemagegn},
  title = {Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {6},
  pages = {176-182},
  doi = {10.11648/j.sjcm.20130206.16},
  url = {https://doi.org/10.11648/j.sjcm.20130206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130206.16},
  abstract = {Background: The aim of this study was to describe the response to nutritional treatment of severely malnourished hospitalized children in relation to HIV infection Methods: The study was conducted in the paediatric wards of Yekatit 12 hospital, which is situated in Addis Ababa, Ethiopia serving as a referral hospital for clinics, health centers and hospitals situated in and out of Addis Ababa. It also serves as a teaching hospital for AAU Medical students and Residents. We studied 300 severely malnourished children (presence of oedema, weight for age 18 months of age, and PCR (DBS) was performed for those <18 months and CD4+ cells were measured for those who turned out to be positive. Complete blood count (CBC), including differential counts, was determined using a Coulter counter and/or manually. The study is a prospective observational analytic cohort study. Result: Of the 300 children, 75 were HIV Positive (cases) and the remaining 225 were controls (1:3 ratio). There was no significant difference by sex, age group, site of residency, family in come, family educational status, medical illness, hematologic profiles, immune category and presence or absence of edema in the treatment out come of HIV infected children compared to uninfected once. Among HIV infected forty three (43/75) failed to respond to the nutritional intervention when compared to those who are not infected (225/38) (Adjusted OR = 6.61, 95%CI = 0.053, 0.423). Conclusion: HIV infection is a major challenge in addressing nutritional intervention for those children who are severely malnourished admitted in Yekatit 12 hospital. An intervention to alleviate the challenge in managing the problem has to be designed based on further interventional studies.},
 year = {2013}
}

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TY  - JOUR
T1  - Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia
AU  - Tesfaye Taye Gelaw
AU  - Amha Mekasha Wondemagegn
Y1  - 2013/11/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130206.16
DO  - 10.11648/j.sjcm.20130206.16
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 176
EP  - 182
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130206.16
AB  - Background: The aim of this study was to describe the response to nutritional treatment of severely malnourished hospitalized children in relation to HIV infection Methods: The study was conducted in the paediatric wards of Yekatit 12 hospital, which is situated in Addis Ababa, Ethiopia serving as a referral hospital for clinics, health centers and hospitals situated in and out of Addis Ababa. It also serves as a teaching hospital for AAU Medical students and Residents. We studied 300 severely malnourished children (presence of oedema, weight for age 18 months of age, and PCR (DBS) was performed for those <18 months and CD4+ cells were measured for those who turned out to be positive. Complete blood count (CBC), including differential counts, was determined using a Coulter counter and/or manually. The study is a prospective observational analytic cohort study. Result: Of the 300 children, 75 were HIV Positive (cases) and the remaining 225 were controls (1:3 ratio). There was no significant difference by sex, age group, site of residency, family in come, family educational status, medical illness, hematologic profiles, immune category and presence or absence of edema in the treatment out come of HIV infected children compared to uninfected once. Among HIV infected forty three (43/75) failed to respond to the nutritional intervention when compared to those who are not infected (225/38) (Adjusted OR = 6.61, 95%CI = 0.053, 0.423). Conclusion: HIV infection is a major challenge in addressing nutritional intervention for those children who are severely malnourished admitted in Yekatit 12 hospital. An intervention to alleviate the challenge in managing the problem has to be designed based on further interventional studies.
VL  - 2
IS  - 6
ER  -

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Author Information

Tesfaye Taye Gelaw

Department of Pediatrics and child health, Bahir Dar University, Bahir Dar, Ethiopia
Amha Mekasha Wondemagegn

Department of Pediatrics and child health, AAU, Addis Ababa, Ethiopia

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Tesfaye Taye Gelaw, Amha Mekasha Wondemagegn. (2013). Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Science Journal of Clinical Medicine, 2(6), 176-182. https://doi.org/10.11648/j.sjcm.20130206.16

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ACS Style

Tesfaye Taye Gelaw; Amha Mekasha Wondemagegn. Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Sci. J. Clin. Med. 2013, 2(6), 176-182. doi: 10.11648/j.sjcm.20130206.16

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AMA Style

Tesfaye Taye Gelaw, Amha Mekasha Wondemagegn. Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia. Sci J Clin Med. 2013;2(6):176-182. doi: 10.11648/j.sjcm.20130206.16

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@article{10.11648/j.sjcm.20130206.16,
  author = {Tesfaye Taye Gelaw and Amha Mekasha Wondemagegn},
  title = {Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {6},
  pages = {176-182},
  doi = {10.11648/j.sjcm.20130206.16},
  url = {https://doi.org/10.11648/j.sjcm.20130206.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130206.16},
  abstract = {Background: The aim of this study was to describe the response to nutritional treatment of severely malnourished hospitalized children in relation to HIV infection Methods: The study was conducted in the paediatric wards of Yekatit 12 hospital, which is situated in Addis Ababa, Ethiopia serving as a referral hospital for clinics, health centers and hospitals situated in and out of Addis Ababa. It also serves as a teaching hospital for AAU Medical students and Residents. We studied 300 severely malnourished children (presence of oedema, weight for age 18 months of age, and PCR (DBS) was performed for those <18 months and CD4+ cells were measured for those who turned out to be positive. Complete blood count (CBC), including differential counts, was determined using a Coulter counter and/or manually. The study is a prospective observational analytic cohort study. Result: Of the 300 children, 75 were HIV Positive (cases) and the remaining 225 were controls (1:3 ratio). There was no significant difference by sex, age group, site of residency, family in come, family educational status, medical illness, hematologic profiles, immune category and presence or absence of edema in the treatment out come of HIV infected children compared to uninfected once. Among HIV infected forty three (43/75) failed to respond to the nutritional intervention when compared to those who are not infected (225/38) (Adjusted OR = 6.61, 95%CI = 0.053, 0.423). Conclusion: HIV infection is a major challenge in addressing nutritional intervention for those children who are severely malnourished admitted in Yekatit 12 hospital. An intervention to alleviate the challenge in managing the problem has to be designed based on further interventional studies.},
 year = {2013}
}

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TY  - JOUR
T1  - Response to Conventional Nutritional Treatment of Severely Malnourished Hospitalized Children in the Context of HIV Infection at Yekatit 12 Hospital, Addis Ababa, Ethiopia
AU  - Tesfaye Taye Gelaw
AU  - Amha Mekasha Wondemagegn
Y1  - 2013/11/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130206.16
DO  - 10.11648/j.sjcm.20130206.16
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 176
EP  - 182
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130206.16
AB  - Background: The aim of this study was to describe the response to nutritional treatment of severely malnourished hospitalized children in relation to HIV infection Methods: The study was conducted in the paediatric wards of Yekatit 12 hospital, which is situated in Addis Ababa, Ethiopia serving as a referral hospital for clinics, health centers and hospitals situated in and out of Addis Ababa. It also serves as a teaching hospital for AAU Medical students and Residents. We studied 300 severely malnourished children (presence of oedema, weight for age 18 months of age, and PCR (DBS) was performed for those <18 months and CD4+ cells were measured for those who turned out to be positive. Complete blood count (CBC), including differential counts, was determined using a Coulter counter and/or manually. The study is a prospective observational analytic cohort study. Result: Of the 300 children, 75 were HIV Positive (cases) and the remaining 225 were controls (1:3 ratio). There was no significant difference by sex, age group, site of residency, family in come, family educational status, medical illness, hematologic profiles, immune category and presence or absence of edema in the treatment out come of HIV infected children compared to uninfected once. Among HIV infected forty three (43/75) failed to respond to the nutritional intervention when compared to those who are not infected (225/38) (Adjusted OR = 6.61, 95%CI = 0.053, 0.423). Conclusion: HIV infection is a major challenge in addressing nutritional intervention for those children who are severely malnourished admitted in Yekatit 12 hospital. An intervention to alleviate the challenge in managing the problem has to be designed based on further interventional studies.
VL  - 2
IS  - 6
ER  -

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